替诺福韦治疗不同HBV基因型HBeAg阳性慢性乙型肝炎疗效差异,本论文可用于诺福韦论文范文参考下载，诺福韦相关论文写作参考研究。
诺福韦论文参考文献：
DOI：10.16662/j.cnki.1674-0742.2017.23.038
[摘 要] 目的 對替诺福韦治疗不同HBV基因型HBeAg阳性慢性乙型肝炎的疗效差异进行分析和研究. 方法 方便选取2014年10月—2015年3月到该院接受治疗的172例不同基因型HBeAg阳性慢性乙型肝炎患者选取为研究对象,治疗之前对患者实施HBV基因分型,记录并对比治疗前和治疗24、96周时乙肝两对半定量、肝功能和HBV-DNA定量,并对比不同HBV基因型患者的抗病毒治疗效果. 结果 172例患者中HBV基因型101例为B基因型,71例HBV基因型为C基因型,未检测到其他基因型,两种HBV基因型的年龄、性别、ALT水平和HBV-DNA水平均差异无统计学意义（P>0.05）.经过治疗后,两种HBV基因型的ALT复常率、HBeAg转阴率、HBV-DNA低于检测下限率和HBeAg血清学转换率均差异无统计学意义（P>0.05）.但和治疗24周时相比,治疗96周后两种HBV基因型患者的ALT复常率、HBeAg转阴率、HBV-DNA低于检测下限率以及HBeAg血清学转换率均有所上升. 结论 替诺福韦对B基因型和C基因型HBeAg阳性慢性乙型肝炎的治疗效果差异无统计学意义.
[关键词] 替诺福韦；HBV基因型；疗效
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）08（b）-0038-03
Different Effects of Tenofovir Treatment with Different HBV Genotypes in HBeAg Positive Chronic Hepatitis B
LIN Tai-shun, CHEN Li-fang, KONG Jin-feng
Mengchao Hepatobiliary Hospital of Fujian Medical University Fujian Medical University Affiliated Infectious Disease Hospital, Fuzhou Infectious Disease Hospital,Section 11, Department of Hepatic Medicine,Fuzhou, Fujian Province, 350025 China
[Abstracts] Objective This paper tries to analyze and study on the differences of efficacy of tenofovir treatment with different HBV genotypes in HBeAg positive chronic hepatitis B. Methods 172 cases of patients with different genotypes of HBeAg positive chronic hepatitis B from October 2014 to March 2015 treated in this hospital were convenient selected, the patients with HBV genotype before treatment were classified, two pairs of semi quantitative and liver function and HBV-DNA of hepatitis B patients before and after treatment with 24 and 96 weeks were recorded and compared, and antiviral therapy effect of different HBV genotype was compared. Results Among the 172 patients, 101 cases of HBV genotype were B genotype, 71 cases of C genotype, and no other genotypes were detected, there were no significant difference between the two genotypes of HBV in the age, gender, ALT level and HBV-DNA level（P>0.05）. After treatment, there was no significant difference in the ALT recovery rate, HBeAg negative rate, HBV-DNA lower than the detection limit rate and the HBeAg seroconversion rate（P>0.05）. However, compared with 24 weeks after treatment, the rate of ALT recovery rate, HBeAg negative rate, HBV-DNA lower than the detection limit rate and HBeAg seroconversion rate were increased in two HBV genotypes after 96 weeks of treatment. Conclusion There are no significant differences in the curative effects of patients with B and C genotype of HBeAg positive chronic hepatitis B by tenofovir method.
结论：关于对写作诺福韦论文范文与课题研究的大学硕士、相关本科毕业论文替诺福韦和恩替卡韦论文开题报告范文和相关文献综述及职称论文参考文献资料下载有帮助。
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